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Michael W Konstan Selected Research

Tobramycin (Nebcin)

11/2021Long-term amikacin liposome inhalation suspension in cystic fibrosis patients with chronic P. aeruginosa infection.
1/2020Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis.
4/2016One-year safety and efficacy of tobramycin powder for inhalation in patients with cystic fibrosis.
7/2014Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial.
6/2014Clinical use of tobramycin inhalation solution (TOBI®) shows sustained improvement in FEV1 in cystic fibrosis.
8/2013Tobramycin inhalation powder manufactured by improved process in cystic fibrosis: the randomized EDIT trial.
7/2012Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis.
3/2011Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: the EVOLVE trial.
1/2011Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial.
7/2007Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosis.
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Michael W Konstan Research Topics

Disease

97Cystic Fibrosis (Mucoviscidosis)
01/2022 - 02/2002
21Lung Diseases (Lung Disease)
11/2021 - 08/2002
13Infections
01/2020 - 04/2002
11Inflammation (Inflammations)
09/2015 - 04/2002
6Pseudomonas Infections
11/2021 - 04/2007
6Disease Progression
01/2020 - 08/2007
5Exocrine Pancreatic Insufficiency
08/2013 - 11/2006
5Cough
07/2013 - 08/2008
4Respiratory Sounds (Crackle)
07/2013 - 08/2007
3Sinusitis
09/2012 - 08/2007
2Pneumonia (Pneumonitis)
06/2021 - 01/2010
2Inborn Genetic Diseases (Disease, Hereditary)
06/2021 - 07/2014
2Bronchiectasis
07/2015 - 03/2014
2Chronic Obstructive Pulmonary Disease (COPD)
04/2015 - 12/2014
2Asthma (Bronchial Asthma)
10/2012 - 06/2005
2Hemorrhage
11/2008 - 12/2007
1Persistent Infection
01/2022
1Dyspnea (Shortness of Breath)
02/2017
1Liver Diseases (Liver Disease)
10/2014
1Acute Kidney Injury (Acute Renal Failure)
07/2014
1Malnutrition (Nutritional Deficiencies)
07/2013
1Respiratory Signs and Symptoms
06/2013
1Ototoxicity
03/2011
1Exanthema (Rash)
11/2010
1Airway Obstruction (Choking)
09/2008
1Steatorrhea
01/2007

Drug/Important Bio-Agent (IBA)

23Anti-Bacterial Agents (Antibiotics)IBA
01/2022 - 12/2002
16ivacaftorIBA
06/2021 - 11/2010
13Tobramycin (Nebcin)FDA LinkGeneric
11/2021 - 03/2003
9Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
01/2022 - 06/2003
8SolutionsIBA
11/2021 - 03/2003
8ChloridesIBA
11/2021 - 02/2002
8lumacaftorIBA
01/2019 - 01/2012
7Ibuprofen (Motrin)FDA LinkGeneric
01/2018 - 12/2002
7EnzymesIBA
10/2014 - 04/2006
6dornase alfa (Pulmozyme)FDA Link
01/2021 - 06/2011
5Pharmaceutical PreparationsIBA
01/2020 - 10/2009
5PowdersIBA
04/2016 - 04/2007
4Biomarkers (Surrogate Marker)IBA
11/2015 - 04/2007
3Amikacin (A.M.K)FDA LinkGeneric
11/2021 - 07/2012
3Anti-Inflammatory Agents (Anti-Inflammatories)IBA
09/2015 - 12/2002
3Peptide Hydrolases (Proteases)FDA Link
07/2015 - 04/2006
3DNA (Deoxyribonucleic Acid)IBA
03/2014 - 06/2003
2ivacaftor drug combination tezacaftorIBA
01/2022 - 01/2021
2SuspensionsIBA
11/2021 - 01/2020
2Liposomes (Liposome)IBA
11/2021 - 01/2020
2prednylidene (Pred)IBA
02/2016 - 10/2006
2Bronchodilator Agents (Bronchodilators)IBA
04/2015 - 12/2014
2Tiotropium Bromide (Spiriva)FDA Link
04/2015 - 12/2014
2CreatinineIBA
07/2014 - 03/2003
2Adrenal Cortex Hormones (Corticosteroids)IBA
01/2009 - 12/2008
2Lipase (Acid Lipase)FDA Link
11/2006 - 04/2006
2AmylasesFDA Link
11/2006 - 04/2006
2Codon (Codons)IBA
10/2005 - 06/2005
2Lysine (L-Lysine)FDA Link
12/2004 - 06/2003
1acebilustatIBA
11/2021
1leukotriene A4 hydrolaseIBA
11/2021
1elexacaftorIBA
01/2021
1Leukocyte Elastase (Neutrophil Elastase)IBA
07/2015
1Pancreatic Elastase (Elastase)IBA
07/2015
1Oxidants (Oxidizing Agents)IBA
07/2015
1colistinmethanesulfonic acid (colistimethate sodium)FDA LinkGeneric
05/2015
1AminoglycosidesIBA
05/2015
1AztreonamFDA LinkGeneric
05/2015
1Proteins (Proteins, Gene)FDA Link
07/2014
1Nonsense Codon (Nonsense Mutation)IBA
07/2014
1atalurenIBA
07/2014
1amelubantIBA
03/2014
1Leukotriene B4IBA
03/2014
1neodymium pyrocatechin disulfonate (NPD)IBA
03/2014
1antineoplaston A10 (A 10)IBA
10/2013
1Bicarbonates (Hydrogen Carbonate)IBA
08/2013
1Interleukin-8B ReceptorsIBA
05/2013
1SB 656933IBA
05/2013
1beta-LactamsIBA
07/2012
1Gentamicins (Gentamicin)FDA LinkGeneric
07/2012
1Human Growth Hormone (Saizen)FDA LinkGeneric
03/2012
1Metalloproteases (Metalloproteinases)IBA
03/2012
1Growth Hormone (Somatotropin)IBA
03/2012
1Linezolid (Zyvox)FDA Link
04/2011
1Glucose (Dextrose)FDA LinkGeneric
11/2010
1Pancrelipase (Creon)FDA Link
01/2010
1Indicators and Reagents (Reagents)IBA
11/2009
1Methicillin (Metin)FDA Link
06/2007
1NitrogenIBA
01/2007
1Coloring Agents (Dyes)IBA
01/2007
1liprotamase lipaseIBA
11/2006
1Ceftazidime (Fortum)FDA LinkGeneric
10/2005
1Meropenem (Merrem)FDA LinkGeneric
10/2005
1Glutamine (L-Glutamine)FDA Link
06/2005
1Glycine (Aminoacetic Acid)FDA LinkGeneric
06/2005

Therapy/Procedure

39Therapeutics
01/2021 - 08/2002
4Enzyme Replacement Therapy
08/2013 - 11/2006
2Respiratory Therapy (Therapy, Respiratory)
01/2018 - 01/2018
2Ambulatory Care (Outpatient Care)
07/2013 - 08/2008
2Duration of Therapy
07/2011 - 07/2007
1Drug Therapy (Chemotherapy)
01/2021
1Nebulizers and Vaporizers (Inhaler)
11/2015
1Secondary Prevention
03/2012
1High-Protein Diet
01/2007